The text appears to be a series of interviews or responses from Sarah Guo, an investor in the biotech and AI space, as well as other experts and founders. The topics covered include:

  • The impact of Y Combinator’s presence on early-stage valuations
  • Due diligence changes in 2022
  • Big Pharma’s interaction with biotech startups
  • Potential effects of US sanctions on China on AI-enabled biotech startups
  • Interest in cold pitches from founders

Some key quotes and takeaways:

  • Sarah Guo mentions that due diligence has become more critical, especially in domains like healthcare, where "confidence in a team’s risk management and ethics is critical."
  • She notes the importance of understanding the domain and the founder’s vision when making investments.
  • In response to US sanctions on China, Sarah suggests that there are real security risks to consider, which may lead to reduced access to global state-of-the-art care for startups.
  • Big Pharma tends to innovate through partnerships with biotechs before acquiring them.

The text also mentions other topics such as:

  • Colossal Biosciences raising $200M at a $10.2B valuation
  • Teal Health raising $10M for at-home cervical cancer screenings
  • Bluesky developing its own photo-sharing app, Flashes